... indirectly regulate theexpressionofthe NOX1 mRNA We therefore elucidated the role of ATF-1 in the MEF2B-dependent activation of NOX1 expression As shown in Fig 6, theexpressionof MEF2B mRNA induced ... cells by inducing theexpressionofthe NOX1 gene Results Determination ofthe 5¢-end ofthe NOX1 mRNA expressed in VSMC We reported theexpressionof novel NOX1 transcripts (c- and f-types) in ... induction of NOX1 expression [8–10] Except for the involvement of ATF-1, the entire picture ofthe transcriptional regulation ofthe NOX1 gene has not been clarified yet In the upstream region of the...
... organization of GP210 and a model ofthe deduced amino acid chain of GP210 Genomic organization of GP210 and a model ofthe deduced amino acid chain of GP210 Exons (black boxes) and intron sizes ... intron, and kb ofthe upstream promoter region of mouse GP210 Similar to human, a GPC island containing 644 bp and with a GC content of 74% was found starting 268 nt upstream ofthe start codon and ... other isoforms of WT1 regulate GP210 Figure WT1 isoform A does not regulate expressionof GP210 WT1 isoform A does not regulate expressionof GP210 SAOS cells conditionally expressing WT1 isoform...
... for for for for for for for expressionof pri-miR9-1 expressionof pri-miR9-1 expressionof pri-miR9-2 expressionof pri-miR9-2 expressionof pri-miR9-3 expressionof pri-miR9-3 neuronal differentiation ... cloned the upstream region of miR9 and studied theexpression pattern of endogenous pri-miR9-1 to try to understand miR9 biogenesis during the neuronal differentiation of P19 cells using RT-PCR and ... positions and sequences used to amplify pri-miR9-1, 9-2 and 9-3 Arrows indicate the position and orientation ofthe primers Bold font represents the sequence of mature miR9* and italic fonts the sequence...
... Equity Balanced Total Equity & Balanced Funds of funds (4) Other Total (excl Ireland & Netherlands) of w hich guaranteed funds Total (incl Ireland & Netherlands) 36,733 in No in % (3) in No (1 No full ... regarding the strength ofthe global economic recovery and increasing tensions in the euro area, which sparked lower demand for equity and bond funds Differences in totals between quarterly and monthly ... billion during the first half of 2011, slightly behind the EUR 55 billion recorded in the first half of 2010 Long-term UCITS attracted EUR 87 billion during the first half ofthe year, down from...
... Funds of funds (4) Other Total (excl Ireland & Netherlands) of w hich guaranteed funds Total (incl Ireland & Netherlands) 35,766 (1 No full data breakdo wn is available fo r Ireland andthe Netherlands; ... during the quarter (4.1%), and net assets of balanced funds reduced by 2.1 percent Funds of funds registered an increase in net assets of 1.7 percent during the quarter Over the first half of 2012, ... Quarter of 2012) Trends in the European Investment Fund Industry Net Assets by Country of Domiciliation The combined assets ofthe investment fund market in Europe, i.e the market for UCITS and nonUCITS,...
... at the end ofthe handle The advantages claimed by the inventor were ease in handling, ease in cleaning, andthe diagonal cut ofthe blades that allowed the blood to flow more freely andthe ... lever on the outside ofthe case The blade was positioned at right angles to the spring and case, thus adopting the basic shape ofthe fleam The case ofthe spring lancet was usually made of copper, ... the first exposing the blades, andthe second rotating them a full 180 degrees Pressure on the release lever pushed the catch off the tooth on the cocking lever, thereby releasing the lever and...
... non-beneficial therapy Understanding repair and identifying targets Interestingly, comparison ofthe fibroblast signature with theexpression profiles of various carcinomas (epithelialderived ... Distinct pattern ofexpressionof differentiation and growth-related genes in squamous cell carcinomas ofthe head and neck revealed by the use of laser capture microdissection and cDNA arrays ... correlating with metastasis, and suggested that the bulk of cells within the tumor share this signature, and thus the metastatic potential is encoded within the bulk ofthe primary tumor [13] This...
... (mean = 54 and median = 55) The genotyping success rate was in the range from 98.2 to 99.5% andthe retesting ofthe 10% randomly selected samples was 100% concordant MMP2 -1306 C/T and -735 C/T ... modify the production of proteolytic enzymes, and in turn modify the risk for melanoma progression Therefore, in this study, we sought to determine whether an association between MMP2 and MMP3 ... manuscript; PR and SS participated in the genotyping; AP coordinated the patients' accrual and updated the clinicopathological and epidemiological database; NI performed the statistical analysis and contributed...
... demonstration of an inverse relationship between NF-κB and p53 nuclear localization and associated protein expression in tumors [35] As a result, and to further examine the validity ofthe results ofthe ... p53 status, which is consistent with either the loss ofthe negative regulation (PTEN and PPAR), or the suppression of NF-κB and other signal pathways and genes by gaining or retaining p53 functions ... alterations andthe biological and clinical significance of NF-κB activation andof multiple NF-κB-regulated genes and cytokines expressed in HNSCC tumor specimens and serum [18,32,33,42,80,81], and the...
... the process of completing this thesis Without the support and encouragement from Dr Lam and Dr Tho, the thesis might not be possible in meeting the requirements and expectations ofthe research ... circumstances In the same meaning, the leadership effectiveness is combined both the qualities ofthe leaders andthe demands ofthe situations In order to make a good decision, the leaders have ... as the leading factor, then other kinds of commitment The results ofthe study reflected the mean scores were consistent with the abovementioned by showing that the affective commitment had the...
... beginning of dive, overall duration of dive, andthe “interdive interval” (the period between the end of one dive event andthe start ofthe next) Most dive events demonstrated a period of rapid ... utilization above and below respective SST and MLDT values for each 24-h period ofthe deployment The structure ofthe transmitted data from the PSATs allows for a re-creation ofthe thermal environment ... northward through the summer The movement ofthe majority ofthe tagged animals in this study northward along the Gulf of Mexico and Atlantic edges ofthe shelf supports the patterns observed by...
... [33] and [34] respectively 24 1.3 Structure ofthe Thesis The rest ofthe thesis is organized as follows First a literature review (Chapter 2) ofthe approaches used to study crystal growth andthe ... interval of 50 ps, na b is the number of events over an interval of 50 ps and a is the average molecules of type a iv The system is then propagated in a Kinetic Monte Carlo simulation on the basis of ... energy, kB is the Boltzmann constant, T is the absolute temperature, and W is the multiplicity ofthe microscopic state The multiplicity ofthe microscopic state, W, is the number of possible combinations...
... change their pI values and affect their mobility in the IPGs Although the phosphorylated/oxidized form of Prx1/6 andthe nitrated form of MnSOD in 2DE remain to be identified, the intensities ofthe ... (Figure 2A) Given the fact that the reduction oftheantioxidantenzymes in the LC at day and day 14 post SCI compared to that in sham-operated tissues (Figure 2A), we examined whether the neural cell ... reduce the possibility ofthe leakage ofthe injected fluid from the site The procedure of animal care was described as above Behavioral Analysis As previously described [24], animals received either...
... contradictory to the conclusions ofthe Final Document ofthe Moscow Meeting ofthe Conference on the Human Dimension ofthe CSCE and in breach of Article 19 ofthe International Covenant on Civil and Political ... or the economic well-being ofthe country, for the prevention of disorder or crime, for the protection of health of morals, or for the protection ofthe rights and freedoms of others Finally, the ... ofthe media across the OSCE region Second, the study assesses the impact these regulations and practices have on the free flow of information andthe freedom ofexpression on the Internet The...
... switch and alters theexpressionofthe two nuclear genome coded isoforms of CytOX V [10,32] The regulation of genes CytOX5a and CytOX5b, coding for the two isofoms Va and Vb, parallels that of genes ... shows the effects of hypoxia on the steady state levels of nuclear genome encoded CytOX IV and Vb mRNAs There was no change in the levels of these mRNAs in macrophages at h of hypoxia, the time ... measured the steady state CytOX mRNA levels The Northern blot in Fig shows the effect of hypoxia on the levels of mitochondrial genome- and nuclear genome-coded mRNAs for CytOX subunits There were...
... ([6] and references therein), suggesting the presence of detectable amounts of PMLA synthetase-specific mRNA The absence of PMLA and polymalatase in other cell types could be the result of cell ... substitutions, eight of them located in the first two b-strands ofthe N-terminal half of NKA48, upstream ofthe homodimer interface and accessible for interactions with other macromolecules It ... settings ofthe Lightcycler Software Version 3.5.3 and conditions in the linear range ofthe PCR-reaction were ensured Cell type expressionof spherulin 3b and polymalatase Quantitative analysis of...
... may have acted on the level of pyrG expression has been removed The strength ofthe feedback regulation of CTP on pyrG expression, i.e the elasticity of pyrG expression for the CTP concentration ... pyrG expression One of these strains has 43% pyrG expression relative to the wild-type and no growth defect at 30 C However, the two strains with the lowest pyrG expression levels at 34% ofthe ... [24] This theory predicts that for biosynthetic pathways, such as those leading to the biosynthesis of amino acids or nucleotides, the control ofthe ux should reside in the demand for the end-product,...
... restores the synthesis of GDP-fucose through the salvage pathway The salvage metabolism accounts for approximately only 10% ofthe intracellular pool of GDP-L-fucose [40] However, theenzymesofthe ... only the de novo pathway alone, but also the salvage pathway could have an essential role in the synthesis of GDP-L-fucose in the cytosol The importance andthe regulatory mechanisms oftheenzymes ... levels of L-fucokinase and pyrophosphorylase The primer and probe sequences and their positions in the mRNA sequence, for GDP-L-fucose pyrophosphorylase andthe short and long splice variants of...
... two bands The slower migrating band always corresponded to the rat brain control, andthe faster migrating band to the N18TG2 control (Fig 5) The existence of both rat and mouse VRL-1 in the same ... only result in one band The slower migrating ofthe two F-11 PCR bands always corresponded to the rat brain control, the faster migrating band to the N18TG2 control In case of C the PCR product from ... vector (Invitrogen) and sequenced The accuracy of sequences from the open reading frame was checked by DNA sequencing of both strands The resulting sequences of specific bands were identical to...
... shows theexpressionof iNOS, MnSOD and COX-2 in glial cells Aβ peptide upregulated the LPSmediated expressionof MnSOD Aβ peptides (1–40) and (1–42) induced theexpressionof iNOS, COX-2, and ... 172 ofthe α1/α2 subunits and on Ser 108 ofthe β subunit of AMPK AICAR treatment of glial cells activated AMPK as evident from the enhanced intensities ofthe phosphospecific protein bands of ... COX-2 expressionand hence to the release of eicosanoids [55,60] ROS are yet another by-product ofthe conversion of arachidonic acid to prostanoids (prostaglandins and leukotrienes), and perhaps...